Cardiovascular genetics research at the University of Pennsylvania
We study the genetic basis of cardiovascular disease using large-scale biobanks and electronic health records.
Our research characterizes how common and rare genetic variation shapes susceptibility to cardiovascular diseases. We use these discoveries to identify therapeutic targets, develop genetic risk prediction tools, and conduct mechanistic clinical studies to validate findings in humans.
We work with the Million Veteran Program, Penn Medicine Biobank, and other population-scale cohorts using computational genetics, epidemiologic methods, and clinical/translational approaches.
Selected Publications
Clark MG, Levin MG. Polygenic Risk Scores for Cardiovascular Disease: Closing the Gap Between Prediction and Practice. JACC. 2026. doi:10.1016/j.jacc.2026.03.089
Sierra-Pagan JE, Levin MG. Cardiovascular Risk Prediction in Breast Cancer Survivors: Are Polygenic Scores Ready for Prime Time? JACC: CardioOncology. 2026;8(1):77-79. doi:10.1016/j.jaccao.2025.12.001
Sharma P, Judy R, Yuan S, Gellatly C, Saxby KL, Rader DJ, Bown MJ, Levin MG, Damrauer SM. Lipoprotein(a) Is Associated With Increased Risk of Abdominal Aortic Aneurysm. JACC: Basic to Translational Science. 2026;11(2):101457. doi:10.1016/j.jacbts.2025.101457.
Levin M, Selvaraj MS, Vy HM, Judy R, Honigberg MC, Bajaj A, Nadkarni GC, Do R, Natarajan P, Denny JC, Loh P-R, Biobank PM. Genetic Prediction of Circulating Lipoprotein(a) Levels in Diverse Populations. 2026. doi:10.64898/2026.02.20.26346738
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P, Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM. Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. Nature Genetics. 2025:1-10. doi:10.1038/s41588-025-02140-2.
Last updated: May 21, 2026